RSO Oil

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Rick Simpson Oil (RSO) is a cannabis extract that contains very high levels of THC alongside other compounds. It was first developed by (and is named for) Rick Simpson, a Canadian medical cannabis advocate who used the extract to treat his skin cancer, then later shared his story around the world. 

Unlike some cannabis concentrates, RSO is a full-spectrum extract, meaning it retains all the cannabinoids, terpenes, and other compounds naturally found in cannabis, maximizing the potential therapeutic effects you receive.

Due to its high THC concentration, RSO is known for its potent psychoactive effects and is primarily used for medicinal purposes, most notably cancer treatment and symptom relief. 

Benefits of RSO: What Is It Used For?

Research suggests RSO has beneficial effects in a variety of use cases:

• Cancer: Preliminary research has indicated that cannabinoids, particularly THC and CBD, may have potential anti-cancer properties, including the ability to induce apoptosis (programmed cell death) in cancer cells and inhibit tumor growth in animal models [1]. 
• Cancer Symptom Management: Preliminary research suggests that THC, CBD, and other cannabinoids found in RSO may have therapeutic benefits for cancer symptoms such as pain, nausea, and appetite loss [2].
• Pain and Inflammation: Research suggests THC and other cannabinoids may have analgesic (pain-reducing) and anti-inflammatory properties [3,4]. Cannabinoids may work by interacting with your body’s endocannabinoid system, which regulates pain perception. 
• Neurological Conditions: Preliminary research suggests that THC, CBD, and the other cannabinoids found in RSO may have neuroprotective properties, potentially benefiting people with neurological conditions [5]. 
• Anxiety and Mood Disorders: RSO, which is high in THC and CBD, may have beneficial properties for mood disorders in lower doses (higher doses of THC may exacerbate anxiety). Preliminary research has found that THC and CBD have potential therapeutic benefits in these sorts of use cases [6,7]. 
• Appetite Stimulation: Research suggests that THC may have appetite-stimulating properties. THC has specifically been researched as an appetite stimulant in cancer patients, and many studies have shown positive results [8]. Given RSO’s high THC content, it may offer these therapeutic benefits. 
• Sleep: RSO is high in THC and CBD, which have sedative and relaxing properties, respectively. THC and CBD have both been researched for their potential therapeutic benefits for sleep disorders [9,10]. 
• Antibacterial Properties: Research suggests cannabinoids may possess antibacterial properties. Cannabinoids have been studied for their effect on antibiotic-resistant strains like MRSA, in particular [11]. RSO is rich in a variety of cannabinoids, meaning it may offer these benefits. 
• Seizure Management: Cannabinoids, particularly CBD, have been investigated for their anticonvulsant properties. Given that RSO is a full-spectrum extract containing CBD and a variety of other beneficial cannabinoids, it might have these properties [12].

How RSO Works in the Body

RSO renders its therapeutic benefits by interacting with the endocannabinoid system (ECS), a complex receptor system in your body that regulates vital functions like mood, pain, sleep, inflammation, and immune response. 

The high THC content in RSO binds to CB1 receptors in the brain and central nervous system, creating psychoactive effects and influencing pain perception, appetite, and mood. 

Meanwhile, the CBD and other cannabinoids in RSO interact with CB2 receptors, which are more prevalent in the immune system and peripheral tissues. 

This full-spectrum interaction (commonly called the entourage effect) allows RSO to comprehensively enhance the function of your ECS, thereby promoting better states of physical and mental health. 

RSO’s concentrated nature allows it to deliver stronger effects than other cannabis products, which is why it’s often used for conditions like cancer, chronic pain, and neurological disorders.

The mechanisms by which RSO works in the ECS are numerous. RSO’s benefits for cancer may be due to the fact that the ECS regulates cell proliferation, apoptosis (programmed cell death), and other processes that influence the presence of cancer cells. 

More research is needed on how RSO renders its benefits, but based on what we know, its interaction with the ECS plays a large part in its therapeutic potential.

RSO Side Effects & Safety Precautions

While RSO is immensely beneficial, it also has the potential to cause side effects – especially due to its high THC levels and psychoactive effects. 

Potential side effects of RSO include: 

• Drowsiness 
• Dry mouth 
• Red eyes 
• Increased appetite 
• Slowed reaction time 
• Anxiety 
• Dizziness

Because of these side effects, we recommend you start with a small dose of RSO and gradually work your way up. The Rick Simpson protocol calls for a drop of oil half the size of a grain of rice, or about 30mg, then recommends you increase this dose over time as your body acclimates to the effects.

For more, see the Rick Simpson protocol and our RSO dosage guide. 

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